Cationic colloidal gold nanorods (GNRs) have a great potential as a theranostic tool for diverse medical applications. GNRs' properties such as cellular internalization and stability are determined by physicochemical characteristics of their surface coating. GNRs modified by (16mercaptohexadecyl)trimethylammonium bromide (MTAB), (MTAB)GNRs, show excellent cellular uptake.
Recent advances in nanotechnology have sparked research in the use of nanoscale particles for medical applications. Gold nanoparticles have become a popular choice of vector in drug delivery research, however, the mechanism of cellular uptake of these particles is still unknown.
toxic. Studies on cellular uptake of gold nanoparticles suggest that nanoparticles are readily endocytosed by mammalian cells and the kinetics depends on the shape and size of the,37 The objective of the present investigation is to study the cytotoxicity, cellular uptake, and biosensing properties of bioconjugated gold nanorods ...
Figure 2 shows how the uptake of GNPs with Citrate, PEG and PEGRME coatings. The Citrate coating is commonly used in the synthesis of GNPs. Whilst citrate coating leads to good cellular uptake, it is not considered suitable for in vivo work, where Polyethylene Glycol (PEG) coatings are .
Cellular uptake efficiency is increased when electrostatic attraction is induced between the cells and the gold nanoparticles. Cell surface modification changes the cellular uptake pathways of the gold nanoparticles and concentrates the gold nanoparticles at the membrane region.
The influence of particle concentration on cellular uptake was analyzed for 5nm and 50nm citratecapped spheres over 24 h, and particle uptake increased as exposure concentration increased.
The cellular uptake mechanism of SPIONs: an invitro study Kiran Vishwasrao1, Yasmin Khan2 and S. Radha1 1University of Mumbai, Vidyanagari, Kalina, Mumbai400098, India 2Sophia College for Women, Bhulabhai Desai Road, Mumbai400026, India Abstract The Superparamagnetic Iron Oxide Nanoparticles (SPIONs) of sizes ranging from 1050 nm
Welldispersed gold nanoparticles (NP) coated with tiopronin were synthesized by Xray irradiation without reducing agents. Highresolution transmission electron microscopy shows that the average core diameters of the NPs can be systematically controlled by adjusting the tiopronin to Au mole ratio in the reaction. Three methods were used to study the NP uptake by cells: quantitative ...
BASIC SCIENCE Nanomedicine: Nanotechnology, Biology, and Medicine 8 (2012) 822 – 832 Research Article Goldpeptide nanoconjugate cellular uptake is modulated by serum proteins Guankui Wang, BS a, Madhusudhan R. Papasani, PhD a, Pallavi Cheguru, PhD a, Patrick J. Hrdlicka, PhD b, Rodney A. Hill, PhD a,⁎ a Department of Animal and Veterinary Science, University .
In this study, we show that cellular uptake efficiency, pathway, and spatial distribution of gold nanoparticles in a cell are significantly modulated based on the surface condition of gold nanoparticles and human cancer cells that were tuned by controlling the pH .
We wished to determine the physicochemical basis for the cellular uptake of this drug, as well as of analogues including the 1:2 adducts of Au(I) with 1,2bis(dinpyridylphosphino)ethane (dnpype; n=2, 3 and 4), and to compare in vitro and in vivo antitumour activity.
Mar 31, 2010· Cellular uptake and toxicity of gold nanoparticles in prostate cancer cells: a comparative study of rods and spheres. GreenMedInfo Summary. In the range of 3090 nm diameter studied, spherical particles of 50 nm in diameter without polyethylene glycol (PEG) had the highest uptake. Surface attachment of PEG reduced cellular uptake.
Next, gold nanoparticles are functionalized with DNA oligonucleotides to target Class A scavenger receptors expressed by C166 cells. Intriguingly, cellular uptake is maximized at a particular AR: shorter nanorods (AR = 2) enter C166 cells more than nanospheres (AR = 1) and longer nanorods (AR = 4 or 7).
Cellular uptake of gold nanoparticles triggered by hostguest interactions Jesús Mosquera,*,† Malou HenriksenLacey,† Isabel García,† Miguel MartínezCalvo, § Jéssica Rodríguez, § José L. Mascareñas§ and Luis M. LizMarzán*,†,‡ †CIC biomaGUNE and CiberBBN, Paseo de Miramón 182, 20014 DonostiaSan Sebastián, Spain ‡Ikerbasque, Basque Foundation for Science, 48013 ...